Good performance hints if you are doing a lot of OLTP processing. Most of the tips will work for Sybase as well.
It is remarkable what performance improvements you can make in an OLTP system if you hire a true database tuning expert to go over your systems with a fine-tooted comb. Unfortunately, the tuning does not usually extend into refactoring the data model. This is because a lot of apps touch the databases, and you would then have to go in and start refactoring app code.
SQL Server 2005 comes with new, easy-to-use profiling tools, and I encourage you to take advantage of them as you are developing new apps. If you are a dev manager, try to get funding for two weeks of a SQL Server 2005 expert's time once your data model is written.
In addition, try to get your SANs tuned correctly, and optimize the interaction between frequenty-used database indexes and the spindles.
How about hardware acceleration, like Solid State Disks?
Kudos go out to this site, completely devoted to SQL Server performance tuning.
Final word - if you have a mission-critical application that involves heavy database access, spend the bucks and hire a DB architect who knows how to tune databases like a 1964 Fender Strat.
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